Author

Alison L. Dickson

University of St AndrewsORCID 0000-0002-4150-2467Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:benchmarking· 1 Assay:metabolomics· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

David James HarrisoniD· 3 shared Greice Michele ZickuhriD· 3 shared Clarissa Melo CzeksteriD· 2 shared Tomáš LébliD· 2 shared Alexander LairdiD· 1 shared Carlin J. Hamill· 1 shared Christopher John HardingiD· 1 shared In Hwa UmiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

David James HarrisonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dimerization and Threonine-Dependent Stabilization Govern Human YRDC Catalysis

Thư Ngọc-Anh Trịnh, Greice Michele Zickuhr, Alison L. Dickson, Silvia Synowksy, Sally L. Shirran, Carlin J. Hamill, Ramasubramanian Sundaramoorthy, Tomáš Lébl, David James Harrison, Clarissa Melo Czekster

This study elucidates the mechanism of YRDC catalysis, showing that threonine stabilizes the enzyme and dimerization is critical for function, with disease-linked mutations disrupting these processes.

bioRxiv · Jul 31, 2026 · PreprintBiochemistry

Improved nucleoside (2'-deoxy)ribosyltransferases maximize enzyme promiscuity while maintaining catalytic efficiency

Peijun Tang, Greice Michele Zickuhr, Alison L. Dickson, Christopher John Harding, Suneeta Devi, Tomáš Lébl, David James Harrison, Rafael G. da Silva, Clarissa Melo Czekster

The paper designs improved nucleoside 2'-deoxyribosyltransferase enzymes with enhanced catalytic efficiency and broad substrate promiscuity for generating diverse nucleoside products.

ACS Chemical Biology · Oct 17, 2025Peer-reviewedBiochemistry

Spatial Metabolomics co-registered with Multiplex Phenotyping for the Evaluation of Human Kidney Tissue

Greice Michele Zickuhr, In Hwa Um, Alexander Laird, David James Harrison, Alison L. Dickson

The paper evaluates a workflow for spatially co-registering molecular and phenotypical data from human kidney tissue using DESI-MSI under varying conditions.

bioRxiv · Nov 10, 2023 · PreprintSystems Biology