Greice Michele Zickuhr

This study elucidates the mechanism of YRDC catalysis, showing that threonine stabilizes the enzyme and dimerization is critical for function, with disease-linked mutations disrupting these processes.

The paper designs improved nucleoside 2'-deoxyribosyltransferase enzymes with enhanced catalytic efficiency and broad substrate promiscuity for generating diverse nucleoside products.

The paper evaluates a workflow for spatially co-registering molecular and phenotypical data from human kidney tissue using DESI-MSI under varying conditions.