Author

Hervé Técher

Centre National de la Recherche ScientifiqueORCID 0000-0002-4161-0791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Audrey Vernet· 1 shared Baptiste LerayiD· 1 shared Clément MettlingiD· 1 shared Diyavarshini GopauliD· 1 shared Jérôme MoreauxiD· 1 shared Jonathan HeuzéiD· 1 shared Philippe PaseroiD· 1 shared Yi‐Ching LiniD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Audrey Vernet

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1 paper

Recent·Most cited

Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases

Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Yi‐Ching Lin, Philippe Pasero

This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.

bioRxiv · Mar 30, 2023 · PreprintMolecular Biology