Author

Yi‐Ching Lin

Centre National de la Recherche ScientifiqueORCID 0000-0003-4063-0771Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Assay:DNA methylation· 2 Organism:E. coli· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Philippe PaseroiD· 4 shared Amandine Basille· 2 shared Connor KirkeiD· 2 shared David CluetiD· 2 shared Emiliano P. RicciiD· 2 shared Laetitia VacheziD· 2 shared Laura Guiguettaz· 2 shared Pascal BernardiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersMolecular Biology

Philippe PaseroORCID

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4 papers

Recent·Most cited

The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids

Yara Bawadi, Amandine Basille, Yi‐Ching Lin, Connor Kirke, Clara Bourgeay, David Cluet, Laetitia Vachez, Virgile Dervieux, Laura Guiguettaz, Pascal Bernard, Stephan Hamperl, Philippe Pasero, Emiliano P. Ricci, Vincent Vanoosthuyse

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

bioRxiv · Sep 24, 2026 · PreprintMolecular Biology

Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks

Mégane Da Mota, Axel Delamarre, Antoine Barthe, Jessica Jackson, Nail Bouzalmad, Alba Torán-Vilarrubias, Yi‐Ching Lin, Cyril Ribeyre, Alessandro Vindigni, Philippe Pasero, Armelle Lengronne

The paper shows condensin and topoisomerases work together to relieve topological stress at stalled replication forks in yeast and human cells.

Nature Communications · May 8, 2026Peer-reviewedGenetics

Rapid delivery of RNase H1 enables replication fork progression under stress independently of R-loop resolution

Amandine Basille, Yi‐Ching Lin, Connor Kirke, David Cluet, Yara Bawadi, Laetitia Vachez, Virgile Dervieux, Laura Guiguettaz, Pascal Bernard, Stephan Hamperl, Philippe Pasero, Emiliano P. Ricci, Vincent Vanoosthuyse

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

bioRxiv · Feb 27, 2025 · PreprintMolecular Biology

Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases

Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Yi‐Ching Lin, Philippe Pasero

This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.

bioRxiv · Mar 30, 2023 · PreprintMolecular Biology