Molecular BiologybioRxivPreprint
Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases
Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé…·Philippe Pasero
This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.
1 citation