Author

Clément Mettling

Centre National de la Recherche ScientifiqueORCID 0000-0002-4963-2928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:GWAS summary statistics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aby Mbengue· 1 shared Adline Delcamp· 1 shared Audrey Vernet· 1 shared Baptiste LerayiD· 1 shared Birane Diouf· 1 shared Catherine BretoniD· 1 shared Charlotte FaurieiD· 1 shared Diyavarshini GopauliD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

Aby Mbengue

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2 papers

Recent·Most cited

Lack of Evidence for Local Adaptation in Risk Tolerance: A Genetic Study in Northern Senegal.

Clément Mettling, Aby Mbengue, Catherine Breton, Gwen-Jirō Clochard, Birane Diouf, Charlotte Faurie, Omar Sene, Adline Delcamp, Erwan Guichoux, Guillaume Hollard, Marc Willinger, Michel Raymond A

This study investigates genetic variation associated with risk tolerance in two Senegalese populations and finds no evidence of local adaptation.

bioRxiv · Sep 17, 2026 · PreprintEvolutionary Biology

Regulation of oncogene-induced senescence by the MRE11 and TREX1 nucleases

Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Yi‐Ching Lin, Philippe Pasero

This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.

bioRxiv · Mar 30, 2023 · PreprintMolecular Biology