Author

Jumanah Yousef Alshenaifi

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-4166-9830Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:multiome· 1

Frequent Co-Authors

Alexey V. SorokiniD· 2 shared Amanda AndersoniD· 2 shared Chi Wut WongiD· 2 shared Hey Min LeeiD· 2 shared John Paul SheniD· 2 shared Natalie Wall FowlkesiD· 2 shared Oscar Eduardo. VillarrealiD· 2 shared Preeti Kanikarla MarieiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Alexey V. SorokinORCID

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Author profile →

2 papers

Recent·Most cited

Reprogramming of Cellular Plasticity via ETS and MYC Core-regulatory Circuits During Response to MAPK Inhibition in BRAF-mutant Colorectal Cancer

Hey Min Lee, Zhao Zheng, Alexey V. Sorokin, Chi Wut Wong, Stefania Napolitano, Saikat Chowdhury, Preeti Kanikarla Marie, Anand Kamal Singh, Veena Kochat, Christopher Aaron Bristow, Sanjana Srinivasan, Michael D. Peoples, Emre Arslan, Jumanah Yousef Alshenaifi, Oscar Eduardo. Villarreal, , Scott Kopetz

This study shows BET + MAPK inhibitors improve efficacy against BRAFV600E CRC by inducing epigenetic reprogramming and cellular plasticity through enhancer dynamics disruption.

Clinical Cancer Research · May 8, 2026Peer-reviewedCancer Biology

Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer

Oscar Eduardo. Villarreal, Yixin Xu, Ha Tran, Annette A. Machado, Dionne Prescod, Amanda Anderson, Rosalba Minelli, Mike Peoples, Alejandro Hernandez Martinez, Hey Min Lee, Chi Wut Wong, Natalie Wall Fowlkes, Preeti Kanikarla Marie, Alexey V. Sorokin, Jumanah Yousef Alshenaifi, , Scott Kopetz

The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.

bioRxiv · Jan 22, 2025 · PreprintCancer Biology