Annette A. Machado

The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.

This study shows RSV gene expression is genotype-dependent and non-gradient, with the G gene consistently more expressed than upstream genes, suggesting a novel transcriptional regulation mechanism involving GS signal N-phase alignment.