Jack A. Wells

This study finds a significant reduction in choroid plexus volume in aged mice using two MRI protocols, supporting previous histology findings of age-related structural changes.

This study investigates how the glymphatic system influences α-synuclein propagation and shows that AQP4 dysfunction may contribute to Parkinson's disease pathology.

This study shows that inhibiting the glymphatic system worsens tau spread and memory issues in a mouse model of Alzheimer's disease.

This study uses MRI to measure blood-cerebrospinal fluid barrier function in a mouse model of Alzheimer's disease, finding increased water delivery through the barrier in early stages.

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.

The paper describes an electrochemical technique using carbon fiber electrodes to simultaneously record brain tissue PO2, pH, and extracellular field potentials in vivo.