Mark F. Lythgoe

Evidence for reduced choroid plexus volume in the aged brain

This study finds a significant reduction in choroid plexus volume in aged mice using two MRI protocols, supporting previous histology findings of age-related structural changes.

Targeted inhibition of Bcl-xL following radiation reduces tumourigenesis in preclinical models of H3K27M-altered diffuse midline glioma

This study shows that combining radiation with Bcl-xL inhibition reduces tumor growth in preclinical models of H3K27M-altered diffuse midline glioma.

Influence of the Glymphatic System on α-Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex

This study investigates how the glymphatic system influences α-synuclein propagation and shows that AQP4 dysfunction may contribute to Parkinson's disease pathology.

Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimers Disease Model

This study shows that inhibiting the glymphatic system worsens tau spread and memory issues in a mouse model of Alzheimer's disease.

CO2 signalling mediates neurovascular coupling in the cerebral cortex

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.

Electrochemical carbon fiber-based technique for simultaneous recordings of brain tissue PO2, pH, and extracellular field potentials

The paper describes an electrochemical technique using carbon fiber electrodes to simultaneously record brain tissue PO2, pH, and extracellular field potentials in vivo.

Impaired brain glymphatic flow in a rodent model of chronic liver disease and minimal hepatic encephalopathy

This study uses MRI in a rat model to show impaired glymphatic flow in brain regions linked to cognitive deficits in chronic liver disease and minimal hepatic encephalopathy.