Isabel N. Christie

Opportunities and pitfalls in preclinical cerebral blood flow mapping using arterial spin labelling MRI: insights from multicentre data

This paper identifies sources of variability in cerebral blood flow measurements using arterial spin labelling MRI in rodents and calls for standardized practices to improve reproducibility.

CO2 signalling mediates neurovascular coupling in the cerebral cortex

This study shows that CO2 signalling is critical for neurovascular coupling in the somatosensory cortex, as disrupting CO2-sensitive vasodilation or HCO3-/CO2 transport abolishes the response to neuronal activity.

Astrocyte mitochondria produce nitric oxide from nitrite to modulate cerebral blood flow during brain hypoxia

The paper shows astrocytes produce nitric oxide from nitrite via mitochondrial sulfite oxidase during hypoxia, modulating cerebral blood flow.

Electrochemical carbon fiber-based technique for simultaneous recordings of brain tissue PO2, pH, and extracellular field potentials

The paper describes an electrochemical technique using carbon fiber electrodes to simultaneously record brain tissue PO2, pH, and extracellular field potentials in vivo.