NeuroscienceMolecular PsychiatryPeer-reviewed
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids
Maria Jose Perez J., Dina Ivanyuk, Vasiliki Panagiotakopoulou…·Michela Deleidi
This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.
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