Maria Jose Perez J.

This paper develops a method to generate human midbrain organoids enriched in SNpc-like dopaminergic neurons using WNT modulation and bioreactor culture, showing improved functionality and vulnerability to Parkinson's disease pathology.

This study investigates how C9orf72 repeat expansion affects metabolism in human iPSC-derived microglia and its impact on glial-neuronal interactions in ALS.

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.

This study shows that IFN-γ and LRRK2 synergize in human neurons and microglia, leading to defects in neurite elongation and microglial activation.