Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids
Maria Jose Perez J., Dina Ivanyuk, Vasiliki Panagiotakopoulou, Gabriele Di Napoli, Stefanie Kalb, Dario Brunetti, Rawaa Al‐Shaana, Stephan A. Kaeser, Sabine A. K. Fraschka, Mathias Jucker, Massimo Zeviani, Carlo Fiore Viscomi, Michela Deleidi
This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.
Molecular Psychiatry · Jul 6, 2020Peer-reviewedNeuroscience