Dario Brunetti

This study shows that mitochondrial stress in human microglia disrupts communication with neurons and promotes senescence, contributing to neurodegenerative processes.

This study shows SURF1 mutations impair human neurogenesis by generating patient-derived iPS cells and demonstrating defects in neuronal differentiation and bioenergetics.

This study shows that PITRM1 deficiency in human cerebral organoids leads to Alzheimer's-like pathology, including protein aggregates and tau pathology, while 2D cultures do not show these features.