Author

Karly M. Fear

University of OregonORCID 0000-0002-4189-9919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Jonathan DoroginiD· 2 shared Justin E. SvendseniD· 2 shared Marian H. HettiaratchiiD· 2 shared Parisa HosseinzadehiD· 2 shared Arash Asgari· 1 shared Ben BurressiD· 1 shared Cassandra GonzaleziD· 1 shared Chandler L. AsnesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioengineering

Jonathan DoroginORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

From Code to Cure: Computationally Designed BMP-2 Binders Using AI-Integrated Pipelines for Controlled Bone Regeneration

Ben Burress, Arash Asgari, Jonathan Dorogin, Karly M. Fear, Cassandra Gonzalez, Justin E. Svendsen, Dylan Merrill, Marian H. Hettiaratchi, Parisa Hosseinzadeh

This paper designs BMP-2 binders using AI pipelines to control bone regeneration, finding a binder with 2.07 nM affinity for BMP-2.

bioRxiv · Aug 21, 2026 · PreprintBioengineering

Applying computational protein design to engineer affibodies for affinity-controlled delivery of vascular endothelial growth factor and platelet-derived growth factor

Justin E. Svendsen, Madeleine R. Ford, Chandler L. Asnes, Simon C. Oh, Jonathan Dorogin, Karly M. Fear, Johnathan R. O’Hara-Smith, Lauren O. Chisholm, Sophia R. Phillips, Michael J. Harms, Parisa Hosseinzadeh, Marian H. Hettiaratchi

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

Biomacromolecules · May 9, 2025Peer-reviewedBioengineering