Masashi Narita

Developmental senescence profiling reveals Eda2r as a common mediator in the core senescence program

The paper identifies Eda2r as a key mediator in both developmental and pathological senescence by profiling senescent cells in mouse limb development and comparing them to in vitro and in vivo models.

Transcription-driven cohesin repositioning rewires chromatin loops in cellular senescence

This study shows that oncogenic HRAS-induced senescence in human fibroblasts involves enhancer-promoter rewiring and dynamic cohesin binding, particularly at SASP genes.

Neuron-specific increase in lamin B1 disrupts nuclear function in Huntington's disease

This study shows increased lamin B1 levels in HD neurons disrupt nuclear function, and reducing lamin B1 with betulinic acid improves nuclear homeostasis and prevents motor and cognitive dysfunction in a mouse model.