Marcus Hacker

Cellular and mitochondrial correlates of regional glucose metabolism in the human cortex

The paper investigates the cellular and mitochondrial factors influencing regional glucose metabolism in the human cortex using multimodal data integration.

Stress-induced Metabolic Remodeling of Adipose and Brain Tissue Revealed by Positron Emission Tomography

This study uses PET and multi-OMICS to show stress activates brown adipose tissue and alters brain metabolism in mice, identifying metabolic hubs and signatures relevant to mental health and disease models.

Amygdala metabolic activity on FDG PET is associated with survival, response to immune checkpoint inhibition, and tumor immune signaling in non-small cell lung cancer

Open-access template and database approaches for pseudo-CT generation in brain PET/MRI attenuation correction

The paper presents an open-access framework for PET attenuation correction using pseudo-CT methods with a database of MRI-CT scans, showing that UCL achieves the lowest quantification error.

Network-specific metabolic cost of functional connectivity in the human brain

The paper examines network-specific metabolic costs of functional connectivity in the human brain using PET/MR data, revealing differences in metabolic demand across brain networks and changes in Alzheimer's disease.

Injury size regulates glucose allocation locally and systemically during vertebrate tissue regeneration

This study shows that injury size affects glucose allocation during tail regeneration in axolotls, with larger injuries leading to increased local and systemic glucose uptake.

Reconfiguration of default mode metabolic demands and network organization during acute stress

This study examines how acute psychosocial stress reconfigures brain metabolism and network organization using PET/MRI, revealing changes in the default mode network and its interactions with other networks.

High-temporal resolution metabolic connectivity resolved by component-based noise correction

This paper develops a noise correction method for high-temporal resolution fPET data, showing it improves metabolic connectivity estimation across different scanners and frequency bands.

A Comparative Evaluation of Molecular Connectivity and Covariance Approaches

This paper compares molecular connectivity (MC) and covariance (mCov) methods using fPET data to assess metabolic associations between brain regions, finding that different methods perform better at varying temporal resolutions.

Evaluation of Data-based Motion Correction Techniques for High Temporal Resolution Functional PET

This study evaluates motion correction techniques for high temporal resolution fPET and finds that neither deep learning nor sliding window averaging significantly improves motion artifact mitigation compared to standard methods.

CD8+ T cells regulate the bioenergetic reprogramming of lymphoid organs and the heart during viral infection

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

Optimal filtering strategies for task-specific functional PET imaging

This study evaluates filtering techniques for fPET data, finding that dNLM and MRI-MRF filters improve signal-to-noise ratio and test-retest reliability, with dNLM reducing sample size needs.

Connecting the Dots: Approaching a Standardized Nomenclature for Molecular Connectivity Combining Data and Literature

The paper introduces a standardized nomenclature for PET-based molecular connectivity and covariance to improve reproducibility and interpretation across imaging modalities and radiotracers.

Non-invasive assessment of stimulation-specific changes in cerebral glucose metabolism with functional PET

This paper introduces a method to assess cerebral glucose metabolism changes during tasks without blood sampling, using GLM beta values and percent signal change, showing strong correlation with standard CMRGlu measurements.

High-temporal resolution functional PET/MRI reveals coupling between human metabolic and hemodynamic brain response

This study uses high-temporal resolution PET/MRI to show synchronized metabolic and hemodynamic brain responses during working memory tasks.

Metabolic demands of the posteromedial default mode network are shaped by dorsal attention and frontoparietal control networks

The paper investigates how metabolic demands of the posteromedial default mode network (DMN) are influenced by task-positive networks during attention-demanding tasks.

Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks

This study investigates how learning affects brain network interactions and metabolic demands, finding that resting-state and task-specific changes in functional connectivity and glucose metabolism are complementary for skill acquisition.

Functional dynamics of dopamine synthesis during monetary reward and punishment processing

The paper introduces a novel fPET approach to assess dopamine synthesis during reward and punishment processing, revealing sex-specific differences in dopamine response to monetary gains and losses.