Elly Margaret Tanaka

This study shows that injury size affects glucose allocation during tail regeneration in axolotls, with larger injuries leading to increased local and systemic glucose uptake.

This study uses a human RPE aging model to show that targeting senescent cells can re-enable injury-responsive repair in aged RPE.

The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.

The paper identifies a defined embryonic window in axolotls during which tail regeneration capacity develops, showing that regenerative competence can be acquired and is distinct from other vertebrates.

The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.

RRE improves de novo repeat libraries by recursively extending repeat models using profile HMMs, resulting in longer and more comprehensive repeat models.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

This study identifies AXL as a key regulator of cardiac regeneration in axolotls and shows its role in inducing cardiomyocyte dedifferentiation in mammals without cell cycle re-entry.

This paper presents an optimized protocol for generating reliable and reproducible neural tube organoids from mouse embryonic stem cells to study early central nervous system development.

The paper compares spinal cord cell types across vertebrates, finding conserved developmental programs and divergent adult compositions, with mammalian-specific neuropeptide expression in the dorsal spinal cord.

The paper shows Notch signaling coordinates germ layer formation and axial polarity in sea anemone gastruloids through a feedback loop with Wnt signaling.

This study investigates the dynamic genomes of Hydra, revealing active transposable elements (TEs) that contribute to genome size variation and structural changes, with evolutionary implications for eukaryotic genomes.

This study demonstrates the use of adeno-associated viruses (AAVs) for efficient gene transfer in the axolotl nervous system, identifying suitable serotypes and applications for neuronal tracing.

The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.

This study identifies divergent stem cell mechanisms in axolotl tail and limb regeneration, showing that TGF-β signaling determines lineage fate of muscle stem cells.

This paper develops a 3D model of human CNS development from naive hiPSCs, showing their ability to form neuroepithelial cysts and model FXS with epigenetic changes.

The paper investigates how Shh+ floor plate cells contribute to spinal cord regeneration in axolotls by tracking their fate and analyzing gene expression dynamics.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

The paper identifies a molecular mechanism for positional memory in limb regeneration, showing that posterior identity is encoded by Hand2 and can be reprogrammed through Shh signaling.

The paper shows how floorplate organiser forms autonomously in neural tube organoids through BMP-mediated cluster competition and FOXA2 dynamics.

The paper identifies two distinct cis regulatory strategies used by CREs to translate graded Shh signaling into differential gene expression in neural progenitors.

The paper identifies segment-specific chromatin states at homeoprotein loci in axolotl limb segments, showing how positional information is encoded for regeneration.

This study investigates the regulation of mesenchymal Amex.Fgf8 expression in axolotl limb development and regeneration, finding that Wnt signaling shifts its target gene activation from epidermis to mesenchyme.

This study uses single-cell genomics to analyze axolotl forebrain cell types, neurogenesis, and regeneration, identifying conserved neuron classes and injury responses.

The paper identifies Tig1 as a regulator of proximo-distal identity during salamander limb regeneration through single-cell RNAseq analysis.

The paper uses modeling and experimental data to show that a signal recruits ependymal cells within a specific spatiotemporal window during axolotl spinal cord regeneration.

This study identifies Prrx1 enhancer-positive dermal fibroblasts as injury-responsive, multipotent cells capable of promoting scar-free wound healing.

The paper investigates how the acto-myosin system regulates YAP activity during liver regeneration in response to bile acid overload.

The paper introduces a non-toxic, simplified tissue clearing method called 2Eci that enables broad applicability across multiple species and tissues.

The paper identifies a conserved LPA signaling pathway that controls apical membrane size and maintains epithelial organization in neuroepithelial rosettes.