Author

Lionel Berthoin

Arsenal Biosciences (United States)ORCID 0000-0002-4236-8802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Aaron R. CooperiD· 1 shared Adam Barner· 1 shared Allyson J. MerrelliD· 1 shared Amaro N Taylor-WeineriD· 1 shared Andrea Fua· 1 shared Andrew Cardozo· 1 shared Angela C. BoroughsiD· 1 shared Ankim Nguyen· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBioinformatics

Aaron R. CooperORCID

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Author profile →

2 papers

Recent·Most cited

DINOcell: Learning Generalizable Perturbation Effects through Self-Distillation

Jonathan Li, Nilgun Tasdemir, Sofia Kyriazopoulou-Panagiotopoulou, Sophie Xu, Allyson J. Merrell, Josephine Susanto, Ashley A. Cass, David DeTomaso, Holly Steach, Julie C. Chow, Li Wang, Neal G. Ravindra, Aram Kang, Grace X. Y. Zheng, Mary Chua, , Amaro N Taylor-Weiner

DINOcell predicts cellular responses to perturbations using self-distillation in single-cell transcriptomics, outperforming baselines for single and combination gene effects.

bioRxiv · Dec 19, 2025 · PreprintBioinformatics

Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling

Jianlong Li, Bo Sun, Li Xuan Tan, Nathan Griffin, Seyyed Vahid Niknezhad, Chieh Yu, Lionel Berthoin, Noel Cruz‐Pacheco, Seayar Mohabbat, Hanan Sinada, Yael Efraim, Feeling Yu Ting Chen, Luye An, Eliza A. Gaylord, Chelsea S. Bahney, , Sarah M. Knox

This study shows that muscarinic agonists can restore non-healing salivary glands by reactivating endogenous regeneration and mitochondrial function through cholinergic-calcium signaling.

bioRxiv · Dec 31, 2024 · PreprintCell Biology