Author

Alexandra E. Perlegos

University of PennsylvaniaORCID 0000-0002-4243-7644Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Aalim M. WeljieiD· 1 shared Anyara RodrigueziD· 1 shared Arjun SenguptaiD· 1 shared Daniel James BoehmleriD· 1 shared Farheen AkhtariD· 1 shared Jaclyn DurkiniD· 1 shared Jenny LuongiD· 1 shared Matthew S. KayseriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Aalim M. WeljieORCID

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1 paper

Recent·Most cited

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathy

Anyara Rodriguez, Jenny Luong, Samuel J. Belfer, Oksana Shcherbakova, Jaclyn Durkin, Pinky Kain, Arjun Sengupta, Alexandra E. Perlegos, Farheen Akhtar, Daniel James Boehmler, Zhecheng Jin, Aalim M. Weljie, Nancy M. Bonini, Matthew S. Kayser

This study shows that peripheral metabolic dysfunction, not just neuronal loss, causes sleep disruption in TDP-43 proteinopathy by identifying SIK3 as a key regulator.

bioRxiv · May 15, 2026 · PreprintNeuroscience