Author

Oksana Shcherbakova

University of PennsylvaniaORCID 0000-0001-7940-3256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Organism:Drosophila· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Nancy M. BoniniiD· 3 shared Shelley L. BergeriD· 2 shared Aalim M. WeljieiD· 1 shared Alexandra E. PerlegosiD· 1 shared Anyara RodrigueziD· 1 shared Arjun SenguptaiD· 1 shared Connor HoganiD· 1 shared Daniel James BoehmleriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Nancy M. BoniniORCID

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Author profile →

3 papers

Recent·Most cited

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathy

Anyara Rodriguez, Jenny Luong, Samuel J. Belfer, Oksana Shcherbakova, Jaclyn Durkin, Pinky Kain, Arjun Sengupta, Alexandra E. Perlegos, Farheen Akhtar, Daniel James Boehmler, Zhecheng Jin, Aalim M. Weljie, Nancy M. Bonini, Matthew S. Kayser

This study shows that peripheral metabolic dysfunction, not just neuronal loss, causes sleep disruption in TDP-43 proteinopathy by identifying SIK3 as a key regulator.

bioRxiv · May 15, 2026 · PreprintNeuroscience

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert, Kevt’her Hoxha, Lesley S. Chaboub, Virginia M.‐Y. Lee, Peter D. Adams, John A. Dani, , Shelley L. Berger

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedNeuroscience

The chromatin conformation landscape of Alzheimer's disease

Raffaella Nativio, Y Lan, Grace D. Donahue, Oksana Shcherbakova, N Barnett, KR Titus, H Chandrashekar, Jennifer E. Phillips‐Cremins, Nancy M. Bonini, Shelley L. Berger

The paper investigates chromatin conformation changes in Alzheimer's disease, finding loss of genomic loops and CTCF dysfunction linked to neurodegeneration.

bioRxiv · Apr 9, 2024 · PreprintNeuroscience