Aalim M. Weljie

This paper demonstrates subcellular mass spectrometry imaging using standard hardware and open-source software, enabling accessible spatial metabolomics with subcellular resolution.

This study combines respirometry and metabolomics to analyze circadian metabolic dynamics in Drosophila, showing how sleep and circadian disruptions affect metabolic rates and redox homeostasis.

This study shows that peripheral metabolic dysfunction, not just neuronal loss, causes sleep disruption in TDP-43 proteinopathy by identifying SIK3 as a key regulator.

The paper shows that suppressing both COX-1 and COX-2 does not cause intestinal injury in mice unless combined with specific NSAIDs, and that gut microbiome changes amplify NSAID-induced enteropathy.

MSI.EAGLE provides an open-source GUI for MSI analysis, integrating advanced tools to simplify data processing and visualization for non-specialists.

This study compares the metabolomic effects of naproxen and celecoxib in humans and mice, finding that naproxen reduces tryptophan levels independently of Cox-2 inhibition.

This study shows that the SCN controls BAT thermogenesis rhythms through sympathetic signaling, independent of adipocyte clocks.

This study examines metabolic changes in Drosophila short sleep mutants during the dark period, revealing altered metabolite levels and rhythmicity patterns compared to wild type.

This study uses isotope tracing to show rhythmic glucose metabolism in Drosophila, revealing internal mechanisms controlling metabolic homeostasis across day and night.

The paper identifies lipidomic biomarkers and therapeutic targets in sepsis patients, including those with COVID-19, and develops an interactive network analysis tool for multiomic data exploration.

This study identifies polyamine elevation and nitrogen stress as toxic consequences of chronic sleep loss in Drosophila, linking them to metabolic dysfunction and reduced survival.

This study identifies CBS-CRY1 binding as a regulatory mechanism linking circadian rhythms and metabolism, showing that CBS modulates CRY1 activity and vice versa.