Matthew S. Kayser

This study identifies EHMT1/G9a's role in sleep regulation through ROS homeostasis in insulin-producing cells, linking it to sleep disturbances in Kleefstra syndrome and common insomnia.

The paper examines how sensory input interacts with sleep regulation in three genetically distinct neurodevelopmental disorder models and identifies impaired sensory-sleep integration as a shared phenotype.

This study identifies monoamine-targeting compounds that rescue neurexin-related behavioral phenotypes in C. elegans and Drosophila, with olanzapine showing broad efficacy across genetic backgrounds.

This study identifies coenzyme Q redox balance as a regulator of dopaminergic neuron activity and juvenile sleep in Drosophila by linking mitochondrial complex I function to sleep fragmentation and depth.

The paper identifies EGR2 as a conserved sleep regulator by analyzing sub-threshold genetic signals across sleep-related traits in multiple species.

This study shows that peripheral metabolic dysfunction, not just neuronal loss, causes sleep disruption in TDP-43 proteinopathy by identifying SIK3 as a key regulator.

The paper identifies beat-Ia/CADM2 as a gene involved in hypersomnia by showing its role in sleep regulation across species and demonstrates potential therapeutic targets.

The paper identifies distinct octopaminergic neuron populations in Drosophila that drive arousal in larvae and adults, revealing a developmental switch in sleep-wake circuit architecture.

This study shows that Drosophila mojavensis larvae sleep less and more deeply than Drosophila melanogaster to prioritize nutrient intake and energy storage, enabling better survival under starvation.

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

This study shows that nutritional status in Drosophila larvae drives the development of sleep-wake rhythms and memory circuits by influencing glucose metabolism and neuronal activity.

This study identifies stem cell-specific ecdysone signaling as critical for generating sleep-promoting neurons in Drosophila and shows its impact on adult sleep behavior.

This study investigates how intrinsic maturation of sleep output neurons influences sleep ontogeny in Drosophila, finding that juvenile and mature sleep differ in transition probabilities and molecular regulation.

This study identifies when circadian sleep emerges in Drosophila larvae and shows its role in enabling long-term memory.

The paper identifies pathogenic variants in SMARCA5 as a cause of a neurodevelopmental syndrome with mild facial dysmorphia and developmental delay.

The paper identifies ISWI as a chromatin remodeler required for adult sleep in Drosophila, with distinct developmental roles in sleep and other behaviors.

This study identifies peripheral chemosensory neuron dysfunction in Drosophila as a cause of social behavioral deficits linked to NF1, showing that Nf1 regulates Ras signaling in ppk23+ neurons to maintain normal social behavior.

This study identifies pdm3 as a gene critical for sleep maturation in Drosophila by coordinating dopaminergic neurite ingrowth and regulating synaptogenesis.

This study shows that selection for starvation resistance in Drosophila melanogaster leads to delayed development and reduced metabolic rate in larvae, which persist into adulthood, along with changes in feeding and sleep behavior.

This paper develops a Drosophila model to study how sleep opportunity restriction improves sleep efficiency and reverses sleep impairments in aging and Alzheimer's disease models.