Attila Losonczy

This paper introduces a geometric framework for analyzing local field potentials (LFPs) by modeling their dynamics as low-dimensional K-tori and validates it across neural datasets.

This study shows that hippocampo-septal feedback inhibits the medial septal circuit based on hippocampal activity and movement speed, without being essential for theta rhythm generation.

The paper shows that recurrent connectivity in hippocampal CA3 subregions shapes spatial coding strategies, with proximal neurons showing stable representations and distal neurons showing dynamic, context-specific activity.

The paper improves three-photon imaging for neuronal activity detection in behaving mice by reducing noise and increasing imaging speed.

The paper links in vivo functional dynamics to molecular identity in hippocampal inhibitory circuits using single-cell transcriptomics and two-photon imaging.

The paper introduces 2P-NucTag, a method to label and profile functionally distinct neurons in vivo, revealing gene expression differences between place and silent hippocampal pyramidal neurons.

The paper shows that clustered excitatory synapses on dendrites improve place field encoding efficiency in hippocampal neurons compared to randomized distributions.

The paper identifies CGE-derived GABAergic interneurons as a key target of rare mutations linked to cognitive deficits in ASD and SCZ using human and mouse models.

This study investigates how input compressibility affects optimal sparsity in sparse autoencoders, finding that optimal coding levels depend on memory demand and input statistics.

The paper uses two-photon imaging and electrophysiological recordings to study dendritic membrane potential dynamics in mouse hippocampal pyramidal cells during behavior, revealing spatial and temporal patterns of electrical signaling.

The paper examines inhibitory interneuron dynamics in 22q11.2 deletion mutant mice during spatial tasks, finding subtype-specific disruptions in activity and microcircuit organization.

This study shows that distal tuft dendrites in hippocampal neurons do not initiate place field formation but instead shape place fields through variable recruitment and local activity.

behaviorMate provides an open-source, flexible system for precise control of behavioral experiments and data collection through an 'Intranet of Things' approach.

This study uses in vivo imaging to show that MEC and LEC axons to CA1 transmit distinct yet overlapping spatial and goal-related signals during navigation.

The paper experimentally tests a model of synaptic plasticity in awake mice, showing asymmetric potentiation and depression of synaptic inputs around plateau spikes and compartment-specific differences in plasticity.

This paper introduces positively tuned GEVIs that enhance spike detection in vivo with standard imaging systems, offering higher temporal resolution than calcium indicators.

The paper describes molecularly-identified CA3 interneuron dynamics during spatial navigation and memory consolidation, showing experience-driven plasticity in inhibitory circuits.

This study investigates how adult born granule cells influence pattern separation by modulating remapping of place and cue cells in the hippocampus.

This paper shows that inhibitory plasticity during hippocampal replay helps infer world structure, with predictions about its impact on cognition and disease.

The paper introduces E-Cannula, a tool for simultaneous electrical and optical recording in the hippocampus, revealing anatomical diversity in sharp-wave ripples and their association with distinct cell assemblies.

The paper investigates how hippocampal neurons rapidly encode new environments through synaptic plasticity mechanisms during novel experiences.

The paper investigates the role of intracellular Ca2+ release in shaping dendritic feature selectivity in hippocampal neurons during spatial navigation.

The paper identifies 'cue cells' in the dentate gyrus that encode sensory cues independently of spatial location, alongside traditional 'place cells', revealing a previously overlooked heterogeneity in DG function.

The paper identifies superhub cells in neural networks that, when targeted, more effectively stabilize epileptic networks compared to traditional hub cells.

The paper shows that offline memory reactivation stabilizes long-term spatial representations by counteracting reward-related biases, promoting comprehensive cognitive maps.

This study uses 2-photon calcium imaging to show that hippocampal network reorganization underlies temporal association memory formation, challenging theories of persistent activity.

This study investigates how adult-born granule cells contribute to epileptic network activity in the dentate gyrus using in vivo calcium imaging and neural topic modeling.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

The paper introduces a zero-inflated gamma model for deconvolved calcium imaging traces, showing it outperforms simpler models in simulated and real neural data.