Toshitaka Nakamura

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

This study shows that ferroptosis and apoptosis can intersect, and BH3-mimetics can either enhance or suppress cell death depending on context.

The paper shows PRDX6 influences ferroptosis sensitivity by managing cellular selenium levels, which affects GPX4 function.