Markus Rehm

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.

This study shows Mcl-1 accumulation and redistribution during the cell cycle increase MOMP thresholds, contributing to cell-to-cell variability in apoptosis susceptibility and intra-tumour heterogeneity.

This study shows stochasticity in protein distributions and interactions contributes to heterogeneity in mitochondrial MOMP during apoptosis, affecting both minority and majority MOMP scenarios.

This study shows that ferroptosis and apoptosis can intersect, and BH3-mimetics can either enhance or suppress cell death depending on context.

This study identifies a novel interaction between BOK and BCL-2 transmembrane domains that regulates apoptosis and suggests it as a potential drug target.

The paper introduces FaST, a tool for parallelising agent-based models of cell signalling on CPUs or GPUs, demonstrating performance improvements of 5.8x and 53.9x.

This paper introduces MAPiT, a method to convert pseudotime scales into real-time and spatial dynamics from single-cell data, applied to cell cycle kinetics and spatial arrangement in spheroids.