Matthias Le Bec

Kinetic and Mechanistic Characterization of RSpFAST, A Non-Covalent Versatile Chemogenetic Platform for Fluorescence Imaging

This paper introduces RSpFAST, a non-covalent chemogenetic platform for fluorescence imaging, and demonstrates its dual behavior as a stable label and a reversible photoswitcher.

Optogenetic spatial patterning of cooperation in yeast populations

This paper uses optogenetics to control cooperation and cheating in yeast populations, showing that cooperation is most effective when cooperator domain size is constrained between two length-scales.

Yeast cell responses and survival during periodic osmotic stress are controlled by glucose availability

This study shows that yeast cell proliferation, survival, and signaling under periodic osmotic stress depend on the phasing of stress with glucose deprivation, highlighting the role of metabolic fluctuations in stress responses.

Optogenetic control of beta-carotene bioproduction in yeast across multiple lab-scales

This study controls beta-carotene production in yeast using optogenetics across different lab-scale devices and finds that illumination, culture volume, and shaking affect performance differently.