Arnaud Gautier

Non-covalent reversibly photoconvertible fluorescent tags for wash-free protein labeling

The paper introduces non-covalent reversibly photoconvertible fluorescent proteins that change color under illumination, enabling discrimination of spectrally similar variants in live cells.

Kinetic and Mechanistic Characterization of RSpFAST, A Non-Covalent Versatile Chemogenetic Platform for Fluorescence Imaging

This paper introduces RSpFAST, a non-covalent chemogenetic platform for fluorescence imaging, and demonstrates its dual behavior as a stable label and a reversible photoswitcher.

Chemically responsive protein switches for the precise control of biological activities

This paper introduces CATCHFIRE and CATCH-ON systems for chemically induced protein dimerization to control biological activities with precision and reversibility.

Chemogenetic timestamping for the precise tracing of cell history into protein assemblies

The paper introduces CATCHFiber, a method to timestamp cellular events with high temporal resolution using self-assembling protein fibers, enabling precise tracking of processes like protein degradation and cell cycle steps.

Chemogenetic modulation of luciferase emission color for imaging and sensing

This paper introduces LumiFAST, a tunable luciferase that enables customizable red-shifted emission for improved imaging and biosensing in live cells.

Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis

The paper shows that unequal mitochondrial segregation during neurogenesis leads to asymmetric cell fates, with fewer mitochondria promoting neuronal differentiation.

Early HIV-1 maturation drives Env clustering and fusion competence

This study shows that early HIV-1 maturation steps, specifically partial Gag cleavage, promote Env clustering and fusion competence by reorganizing the membrane-proximal lattice.

Characterizing drug activity with sensitive interactomes in human living cells

The paper introduces a method to identify drug-sensitive protein-protein interactions in live cells using ERK1 as a case study, showing how inhibitory molecules affect these interactions.

Super-resolution live-cell mapping of protein-protein interactions using chemogenetic split reporters and STED microscopy

This paper introduces a method combining chemogenetic split reporters and STED microscopy to map protein-protein interactions in live cells with sub-diffraction resolution.

Peptide-functionalized fluorescent polymeric nanoparticles: polysarcosine length defines stealth properties

This study shows that polysarcosine length affects nanoparticle stealth properties, enabling specific protein targeting with minimal non-specific interactions.

A tunable and versatile chemogenetic near infrared fluorescent reporter

The paper introduces nirFAST, a tunable NIR fluorescent reporter for multiplexed imaging, enabling subdiffraction resolution and cell cycle monitoring in live cells.

Multiplexed in vivo imaging with fluorescence lifetime modulating tags

This paper introduces FAST tags that modulate fluorescence lifetime to enable multiplexed imaging of up to six targets in live cells and zebrafish embryos.

Engineering of a fluorescent chemogenetic reporter with tunable color for advanced live-cell imaging

The paper engineers a fluorescent chemogenetic reporter with tunable color for live-cell imaging, enabling advanced spectral control and compatibility with advanced imaging techniques.

Orthogonal fluorescent chemogenetic reporters for multicolor imaging

The paper introduces two spectrally orthogonal chemogenetic tags for multicolor live cell imaging, enabling detection of early cell cycles and protein interactions.

A far-red fluorescent chemogenetic reporter for in vivo molecular imaging

This paper introduces frFAST, a far-red fluorescent protein that enables high-contrast imaging in live organisms and facilitates the design of chemogenetic reporters for protein interactions.