Author

Dirk Eggink

National Institute for Public Health and the EnvironmentORCID 0000-0002-4248-6008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A MeijeriD· 1 shared Alexander Byrne· 1 shared Alvin X. HaniD· 1 shared Annelies de RooijiD· 1 shared Björn F. KoeliD· 1 shared Christine Carr· 1 shared Colin A. RusselliD· 1 shared Derek Smith· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

A MeijerORCID

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2 papers

Recent·Most cited

Long-term experimental evolution of seasonal influenza A/H3N2 virus reveals diverse evolutionary potential

Annelies de Rooij, Katina D. Hulme, Sarah van Leeuwen, Karen de Haan, Laura E. van Groeningen, Marliek van Hoesel, Zandra C. Félix Garza, Dirk Eggink, Simon P. J. de Jong, Alvin X. Han, Colin A. Russell

This study shows that A/H3N2 influenza virus evolves differently in independent human airway cultures, with limited parallelism and novel mutations, suggesting evolutionary paths are influenced by selective context rather than intrinsic constraints.

bioRxiv · Oct 27, 2026 · PreprintEvolutionary Biology

Emergence and antigenic characterisation of influenza A(H3N2) viruses with hemagglutinin substitutions N158K and K189R during the 2024/25 influenza season

Björn F. Koel, Alexander Byrne, Samuel A. Turner, Sarah L. James, Ruth Harvey, Mónica Galiano, Christine Carr, Pascal Lexmond, Mark Pronk, Ruonan Liang, Geert‐Jan Boons, Robert P. de Vries, Dirk Eggink, Nicola S. Lewis, Derek Smith, , Ron A. M. Fouchier

This study characterizes the emergence and antigenic properties of influenza A(H3N2) viruses with N158K and K189R substitutions, showing they are antigenically distinct from vaccine strains and may reduce vaccine effectiveness.

bioRxiv · Feb 10, 2026 · PreprintMicrobiology