Author

Sarah L. James

University of CambridgeORCID 0000-0002-6969-1167Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Pascal Lexmond· 2 shared Ron A. M. FouchieriD· 2 shared A MeijeriD· 1 shared Adinda KokiD· 1 shared Alexander Byrne· 1 shared Björn F. KoeliD· 1 shared Christine Carr· 1 shared David F. BurkeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

Pascal Lexmond

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2 papers

Recent·Most cited

Emergence and antigenic characterisation of influenza A(H3N2) viruses with hemagglutinin substitutions N158K and K189R during the 2024/25 influenza season

Björn F. Koel, Alexander Byrne, Samuel A. Turner, Sarah L. James, Ruth Harvey, Mónica Galiano, Christine Carr, Pascal Lexmond, Mark Pronk, Ruonan Liang, Geert‐Jan Boons, Robert P. de Vries, Dirk Eggink, Nicola S. Lewis, Derek Smith, , Ron A. M. Fouchier

This study characterizes the emergence and antigenic properties of influenza A(H3N2) viruses with N158K and K189R substitutions, showing they are antigenically distinct from vaccine strains and may reduce vaccine effectiveness.

bioRxiv · Feb 10, 2026 · PreprintMicrobiology

A vaccine antigen central in influenza A(H5) virus antigenic space confers subtype-wide immunity

Adinda Kok, Samuel H. Wilks, Sina Türeli, Sarah L. James, Theo M. Bestebroer, David F. Burke, Mathis Funk, Stefan van der Vliet, Monique I. J. Spronken, Willemijn F. Rijnink, David J. Pattinson, Dennis de Meulder, Miruna E. Rosu, Pascal Lexmond, Judith M. A. van den Brand, , Mathilde Richard

The paper creates a high-resolution antigenic map of A(H5) HA and uses it to design vaccine antigens that confer broad immunity against diverse A(H5) viruses.

Nature · Oct 15, 2025Peer-reviewedMicrobiology