This study identifies lipid mono-unsaturation as a mechanism for cold tolerance in frogs and shows its potential to improve tissue viability during hypothermic storage.

bioRxiv · Feb 11, 2026 · PreprintBiochemistry

Structural basis of underwound DNA topology bearing PAM-mutant recognition by AtCas9

Min Duan, Bing Meng, Lei Zhou, Lijie Wu, Xiaohan Tong, Dongchao Huang, Hao Yin, Zheng Liu, Ying Zhang

This study reveals how DNA topology affects PAM recognition by AtCas9 through cryo-EM structures of underwound DNA complexes.

bioRxiv · Jan 30, 2026 · PreprintBiochemistry

Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes: Is rRNA Fragmentation Linked to Translational Fidelity?

Cristina Gutierrez‐Vargas, Swastik De, Suvrajit Maji, Zheng Liu, Zhonghe Ke, Martina Nieb, Andrei Seluanov, Vera Gorbunova, Joachim Frank

The paper compares ribosome structures of naked mole-rats, tuco-tucos, and guinea pigs, finding fragmented 28S rRNA in the former with potential links to high translational fidelity.

Nucleic Acids Research · Jan 9, 2026Peer-reviewedBiochemistry

DNA-based ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells

Yuru Hu, Hongyun Li, Chen Zhang, Jingjing Feng, Wenxu Wang, Wei Chen, Miao Yu, Xinping Liu, Xinghua Zhang, Zheng Liu

This paper introduces DNA-based ForceChrono probes to measure single-molecule force dynamics in living cells, revealing precise loading rates and a link between force magnitude and duration.

Cell · Jun 1, 2024Peer-reviewedBiophysics