Dysregulation of Nitrosylation Dynamics Promotes Nitrosative Stress and Contributes to Cardiometabolic Heart Failure with Preserved Ejection Fraction
Zhen Li, Kyle Brian LaPenna, Natalie Gehred, Xiaoman Yu, W.H. Wilson Tang, Jake E. Doiron, Huijing Xia, Jingshu Chen, Ian H. Driver, Frank B. Sachse, Naoto Muraoka, Antonia Katsouda, Paraskevas Zampas, Amelia G. Haydel, Heather D. Quiriarte, , David J. Lefer
This study identifies dysregulated nitrosylation dynamics in HFpEF patients and ZSF1 obese rats, showing elevated nitrosative stress markers and impaired trans- and de-nitrosylase activity.
Circulation Research · Sep 17, 2025Peer-reviewedPhysiology