Author
University of California San DiegoORCID 0000-0001-8609-2548Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Angela Lackner, Sofia I. Picucci, Wenjin Jiang…·Reginald McNulty
This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.
Roni Klein, Janset Onyuru, Jessica L. Centa…·Michelle L. Hastings
This study uses antisense oligonucleotides to modulate NLRP3 splicing, reducing its inflammatory activity and systemic inflammation in mouse models.
Isaac Shamie, Meghan Bliss‐Moreau, Jamie Casey Lee…·Ben A. Croker
The paper investigates lineage commitment bias in human and murine hematopoietic stem cells, finding that variation in myeloid and lymphoid engraftment is stochastic and not due to cell-intrinsic bias.
Chenyang Guan, Seungjin Ryu, Mingze Dong…·Vishwa Deep Dixit
This study shows that elevated taurine reduces age-related inflammation by inhibiting the NLRP3 inflammasome and pyroptosis in mice.