This study compares Tau oligomer properties in slowly and rapidly progressive Alzheimer's disease, finding distinct biochemical and proteomic profiles associated with different clinical progression rates.

bioRxiv · Dec 13, 2025 · PreprintNeuroscience

Proteomic and Kinetic Characterization of Prion Seeding in Distinct Human CJD Strains Unveils Early Diagnostic Biomarkers

Saima Zafar, Neelam Younas, Jean‐Yves Douet, Mathias Schmitz, Niccolò Candelise, Susana Correia, Olivier Andréoletti, Inga Zerr

The paper uses RT-QuIC and proteomics to analyze prion seeding activity and identify early diagnostic biomarkers in human CJD strains.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer's disease

Tayyaba Saleem, Matthias Schmitz, Saima Zafar, Susana Correia, Leticia Camila Flores Fernandez, Anna-Lisa Fischer, Carolina Thomas, Stefan Goebel, Wiebke Möbius, Abrar Younas, Péter Hermann, Christine Stadelmann, Olivier Andréoletti, Isidró Ferrer, Neelam Younas, Inga Zerr

This study characterizes stress granule structural and molecular changes in Alzheimer's disease subtypes using multi-omics approaches, revealing distinct features in rapidly progressive AD.

bioRxiv · Jul 20, 2025 · PreprintNeuroscience

Genome wide association study of clinical duration and age at onset of sporadic CJD

Holger Hummerich, Helen E. Speedy, Tracy Campbell, Lee Darwent, Elizabeth Hill, Steven John Collins, Christiane Stehmann, Gábor Géza Kovács, Michael D. Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpí, Adriano Aguzzi, Sven J. van der Lee, Cornelia M. van Duijn, , Simon Mead

This study identifies genetic variants associated with clinical duration in sporadic CJD but finds no significant SNPs for age at onset.

PLoS ONE · Jul 26, 2024Peer-reviewedGenetic & Genomic Medicine