Matthias Schmitz

Detection of alpha synuclein seeding activity in tear fluid in patients with Parkinson's disease

This study detects alpha-synuclein seeding activity in tear fluid from Parkinson's disease patients using aSynSAA, showing higher activity in PD compared to controls and prion disease.

Tau oligomer heterogeneity and associated protein profile in slowly versus rapidly progressive Alzheimer's disease

This study compares Tau oligomer properties in slowly and rapidly progressive Alzheimer's disease, finding distinct biochemical and proteomic profiles associated with different clinical progression rates.

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer's disease

This study characterizes stress granule structural and molecular changes in Alzheimer's disease subtypes using multi-omics approaches, revealing distinct features in rapidly progressive AD.

Gpnmb Defines a Phagocytic State of Microglia Linked to Neuronal Loss in Prion Disease

The paper identifies Gpnmb as a marker of a phagocytic microglial state linked to neuronal loss in prion disease, showing its role in clearing apoptotic cells.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.