The schizophrenia associated protein DISC1 is a multivalent tetrameric hub of conserved ancient fold
Jin Chuan Zhou, Jiří Kratochvíl, Fei Ye, Kamel El Omari, Philipp Kukura, Mingjie Zhang, Elena Seiradake
This study presents the cryo-EM structure of DISC1, revealing its homotetrameric architecture and its ability to bind multiple partner proteins.
bioRxiv · Jan 30, 2026 · PreprintNeuroscience