Kenneth Paigen

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.

The paper examines two catalytic mutations in PRDM9, showing they affect methyltransferase activity differently in full-length versus isolated PR/SET domain, revealing non-modular behavior.

The paper shows that sex-specific modifiers, like CHK2, allow female fertility without PRDM9, revealing sex-specific regulation of meiotic recombination.

The paper shows HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hotspots, enabling DSB machinery access and preventing sterility in male mice.

The paper identifies tissue-specific trans-regulation of H3K4me3 levels in mouse cell types and links it to histone quantitative trait loci (hQTL) associated with zinc finger genes.

The paper estimates the health effects of rare gene knockouts in adults by analyzing exome sequencing data and health records, finding no significant disease associations.