Guruprasad Ananda

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

This study identifies novel genetic modifiers of late-onset Alzheimer's disease by stratifying patients into molecular subtypes using transcriptomic data and whole genome sequencing.

The paper shows HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hotspots, enabling DSB machinery access and preventing sterility in male mice.

The paper develops bioinformatics workflows to analyze genomic data from patient-derived xenografts, addressing challenges like separating mouse and human reads and identifying somatic mutations without paired normal DNA.

The paper generates a new de novo genome assembly for C57BL/6J Eve, addressing genetic drift in the reference strain and improving genomic accuracy.

The paper identifies tissue-specific trans-regulation of H3K4me3 levels in mouse cell types and links it to histone quantitative trait loci (hQTL) associated with zinc finger genes.

This study quantifies intratumoral subclone dynamics in breast cancer xenografts, revealing a treatable ecology where subclone ratios predict treatment response.