Christopher L. Baker

The paper describes a panel of genetically diverse embryonic stem cells from Diversity Outbred mice to study natural genetic variation's impact on pluripotency and differentiation.

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

The paper identifies trans-acting genetic variation that regulates 3D chromatin interactions through heterochromatin formation, showing how this mechanism coordinates chromatin state and gene expression changes.

The paper identifies eQTL in mouse neural progenitor cells and shows their effects on gene regulation across developmental stages.

Enhlink infers enhancer-promoter linkages using scATAC-seq data and outperforms existing methods, revealing a super-enhancer regulating striatal neuron markers.

The paper uses regression modeling to identify genetic-epigenetic interactions in mice, showing they are common and structured by 3D chromatin domains.

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.

This study integrates multi-omics data from mouse embryonic stem cells to identify genetic drivers of proteome variability and uncover regulatory mechanisms in pluripotency.

The paper shows genetic variation in mouse ESCs affects lineage commitment by modulating pluripotency epigenome regulators, with B6 and D2 strains showing distinct differentiation biases.

This study identifies Period-2 and Nonsense Mediated Decay as regulators of CKI levels, affecting circadian period in Neurospora crassa.

The paper shows EWSR1 is essential for PRDM9-dependent histone methylation and linking recombination hotspots to the chromosome axis during meiosis.

The paper shows HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hotspots, enabling DSB machinery access and preventing sterility in male mice.

The paper identifies genetic variants influencing metastability in mouse embryonic stem cells by analyzing gene expression and chromatin accessibility in 185 genetically diverse cells.

The paper identifies tissue-specific trans-regulation of H3K4me3 levels in mouse cell types and links it to histone quantitative trait loci (hQTL) associated with zinc finger genes.