Author

Donna K. Klinedinst

Johns Hopkins UniversityORCID 0000-0002-9901-3682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:zebrafish· 1

Frequent Co-Authors

Roger H. ReevesiD· 3 shared Fabian‐Xosé FernandeziD· 2 shared Alena V. SavonenkoiD· 1 shared Andrew S. McCallioniD· 1 shared Anna J. MoyeriD· 1 shared Bei Cheng· 1 shared Benjamin DevenneyiD· 1 shared Carmen C. Leitch· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersGenetics

Roger H. ReevesORCID

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3 papers

Recent·Most cited

Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

Anna J. Moyer, Fabian‐Xosé Fernandez, Yicong Li, Donna K. Klinedinst, Liliana Florea, Yasuhiro Kazuki, Mitsuo Oshimura, Roger H. Reeves

The paper identifies multiple chromosome 21 genes that modulate Sonic hedgehog signaling, which is dysregulated in Down syndrome.

Disease Models & Mechanisms · Mar 30, 2023Peer-reviewedGenetics

Forebrain Shh overexpression improves cognitive function in a Down syndrome mouse model and euploid littermates

Feng Gao, Donna K. Klinedinst, Fabian‐Xosé Fernandez, Bei Cheng, Alena V. Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper, Roger H. Reeves

This study shows that overexpressing Shh in the forebrain of Down syndrome mice improves cognitive function, while cerebellar Shh overexpression does not.

Acta Neuropathologica Communications · Aug 16, 2021Peer-reviewedNeuroscience

Survey of human chromosome 21 gene expression effects on early development in Danio rerio

Sarah Edie, Norann A. Zaghloul, Carmen C. Leitch, Donna K. Klinedinst, Janette Lebron, Joseph F. Thole, Andrew S. McCallion, Nicholas Katsanis, Roger H. Reeves

The paper screens Hsa21 gene overexpression in zebrafish to study dosage-sensitive effects on early development and identify potential contributors to Down syndrome pathology.

G3 Genes Genomes Genetics · May 14, 2018Peer-reviewedGenetics