Nicolás Marichal

The paper shows that brain injury reactivates a developmental program in astrocytes to generate transient LGE-class interneurons that integrate into neural circuits.

This study shows that astrocytes can be converted into functional neurons in the mouse visual cortex, which can integrate into cortical circuits and respond to visual stimuli.

This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.

This study reprograms early cortical astroglia into neurons with parvalbumin-positive interneuron features using a modified Ascl1 protein.

This study shows that Ascl1 induces low-efficiency neuronal reprogramming of proliferative glia in vivo, unlike its efficient in vitro conversion.

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.