Robert J. Goldstone

This study shows that ATRX mutation type affects chromatin response to retinoic acid in neuroblastoma, influencing differentiation and therapeutic response.

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

This study identifies a novel RNA-binding function of PGC-1alpha that couples transcriptional co-activation with mRNA nuclear export and mitochondrial homeostasis.

This paper introduces dual perturb-seq, a method combining CRISPR screening and single-cell RNA-sequencing to identify host-microbe transcriptional interactions, revealing new effector proteins in Toxoplasma gondii.

This study shows ASCL1 interacts with mSWI/SNF complexes to regulate chromatin structure and gene expression during human neurogenesis.

This study identifies transcriptional and chromatin changes during astrocyte maturation in vivo and in culture, showing that extrinsic signals regulate intrinsic transcription factors to drive maturation.