Author

Sydney Leaman

King's College LondonORCID 0009-0008-4100-0601Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexis CooperiD· 2 shared Ana Beltrán-ArranziD· 2 shared Araceli Garcia-MoraiD· 2 shared Benedikt BerningeriD· 2 shared Nicolás MarichaliD· 2 shared Adil KhaniD· 1 shared Filipe Machado FerreiraiD· 1 shared François GuillemotiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Alexis CooperORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Functional recruitment of astrocyte-derived neurons into the mouse visual cortex

Sydney Leaman, Filipe Machado Ferreira, Lin Dong, Ana Beltrán-Arranz, Jerónimo Jurado‐Arjona, Araceli Garcia-Mora, Alexis Cooper, Nina Treder, Syauqina Fakhira, Varun Sreenivasan, Nicolás Marichal, Óscar Marín, Adil Khan, Benedikt Berninger

This study shows that astrocytes can be converted into functional neurons in the mouse visual cortex, which can integrate into cortical circuits and respond to visual stimuli.

bioRxiv · Jan 27, 2026 · PreprintNeuroscience

Dlx2 reprograms the transcriptome and laminar position of glia-derivedAscl1-induced interneurons

Alexis Cooper, Araceli Garcia-Mora, G. Herrera-Oropeza, Ana Beltrán-Arranz, Nicolás Marichal, Youran Shi, Sydney Leaman, Karla Lozano Gonzalez, Molly Strom, Fursham Hamid, François Guillemot, Benedikt Berninger

This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.

bioRxiv · Jan 2, 2026 · PreprintNeuroscience