Graham J. Leggett

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

The paper develops a computational method to design proteins that bind small molecules tightly and specifically, validated experimentally with X-ray crystallography and functional assays.

This paper designs and characterizes peptide barrels that can bind and catalyze reactions between small molecules in solution.

This paper describes a computational method for designing -helical-barrel proteins with small molecule-binding channels, achieving high expression and structural accuracy in E. coli.