Joel J. Chubb

The paper designs de novo all-α-helical proteins using computational methods and validates their stability and structure.

This paper designs globular proteins that drive biomolecular condensation and demonstrates their use in forming dynamic condensates in cells.

The paper develops a computational method to design proteins that bind small molecules tightly and specifically, validated experimentally with X-ray crystallography and functional assays.

This paper designs A3B3 heterohexameric alpha-helical barrels by controlling heptad register, showing that it affects helix orientation and using AlphaFold-Multimer for modeling.