Cancer BiologybioRxivPreprint
TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications
Arunachalam Sekar, Rishita Chatterjee, Boobash Raj Selvadurai…·Yosef Yarden
This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.
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