Author

Anson T. Ku

National Institutes of HealthORCID 0000-0002-6471-5502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Adam G. SowalskyiD· 3 shared Aakanksha VermaiD· 1 shared Alejandro A. SchäfferiD· 1 shared Alessandro GennaiD· 1 shared Alex TokeriD· 1 shared Andrew E. GreensteiniD· 1 shared Ariel AfekiD· 1 shared Arunachalam SekariD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Adam G. SowalskyORCID

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3 papers

Recent·Most cited

Androgen deprivation-mediated activation of AKT is enhanced in prostate cancer with TMPRSS2:ERG fusion

Fen Ma, Sen Chen, Luigi Giovanni Cecchi, Betul Ersoy-Fazlioglu, Joshua W. Russo, Seiji Arai, Seifeldin Awad, Carla Calagua, Fang Xie, Larysa Poluben, Olga S. Voznesensky, Anson T. Ku, Fatima H. Karzai, Changmeng Cai, David Johnson Einstein, , Steven P. Balk

This study shows that in prostate cancer with TMPRSS2:ERG fusion, androgen deprivation increases AKT activation, which may reduce the effectiveness of AR-targeted therapy, suggesting combination therapy could be beneficial.

Journal of Clinical Investigation · Oct 2, 2025Peer-reviewedCancer Biology

TMPRSS2-ERG confers resistance to antiandrogens: mechanism and therapeutic implications

Arunachalam Sekar, Rishita Chatterjee, Boobash Raj Selvadurai, Lipika R. Pal, Aakanksha Verma, Nishanth Belugali Nataraj, Diana Drago Garcia, Suvendu Giri, Alessandro Genna, Feride Karatekin, Nitin Gupta, Mirie Zerbib, Yaron Vinik, Tamir Avioz, Eviatar Weizman, , Yosef Yarden

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.

bioRxiv · Jan 17, 2025 · PreprintCancer Biology

Comparison of Approaches to Transcriptomic Analysis in Multi-Sampled Tumors

Anson T. Ku, Scott C. Wilkinson, Adam G. Sowalsky

This study compares five methods for analyzing gene expression in multi-sampled prostate tumors and benchmarks linear mixed models against generalized linear models for differential expression analysis.

Briefings in Bioinformatics · Jul 29, 2021Peer-reviewedBioinformatics