This study identifies 30 genome-wide significant loci for obsessive-compulsive disorder (OCD) using a large GWAS, linking risk to specific brain cell types and shared genetic risk with other psychiatric and non-psychiatric traits.

Research at the University of Copenhagen (University of Copenhagen) · Jan 1, 2025Peer-reviewedGenetic & Genomic Medicine

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

Christie L. Burton, Mathieu Lemire, Bowei Xiao, Elizabeth C. Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S.‐M. Shaheen, Tara Goodale, Vanessa M. Sinopoli, Kathleen D. Askland, Cristina Barlassina, Oscar Joseph Bienvenu, Donald W. Black, , Andrew D. Paterson

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

Translational Psychiatry · Feb 2, 2021Peer-reviewedGenomics

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

Joanna Martin, Ekaterina A. Khramtsova, Slavina B. Goleva, Gabriëlla A.M. Blokland, Michela Traglia, Raymond Kenney Walters, Christopher Hübel, Jonathan R. I. Coleman, Gerome D. Breen, Anders Dupont Børglum, Ditte Demontis, Jakob Grove, Thomas Mears Werge, Janita Bralten, Cynthia Marie Bulik, , Eli Stahl

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

Biological Psychiatry · Jan 10, 2021Peer-reviewedGenetics