Michael J. Giannetto

Multimodal imaging maps spinal glymphatic transport in health and its disruption after injury

This study maps glymphatic transport in the spinal cord using imaging and shows that it is disrupted after injury, with impaired clearance and worsened outcomes in AQP4-knockout mice.

Enhanced glymphatic CSF tracer influx during α2-adrenergic agonist anesthesia is independent of tracer injection duration

This study shows that α2-adrenergic agonist anesthesia increases glymphatic CSF influx, independent of tracer injection duration, compared to isoflurane.

Structural characterization of SLYM - a 4th meningeal membrane

The paper identifies and characterizes SLYM, a potential fourth meningeal membrane, using imaging and histological analysis in mice.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

This study examines how AQP4 deletion affects glymphatic function using diffusion MRI techniques, finding altered brain fluid dynamics and reduced glymphatic influx in AQP4 KO mice.